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Abstract


Home > Archives

IJPASA-Volume 1 Issue 1 2012, APR-JUN

Pages: 1-8

FORMULATION AND INVITRO EVALUATION OF SUBLINGUAL TABLETS CONTAINING TAMSULOSIN HYDROCHLORIDE FOR FAST ORO-MUCOSAL ABSORPTION

Author: Sandeep M, K Muthusamy, Harsha vardan reddy

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Abstract

The present aim was to formulate sublingual tablets containing tamsulosin hydrochloride which is a drug for benign prostatic hyperplasia condition and urinary tract infection; formulations were evaluated by performing comparative studies. Tamsulosin hydrochloride undergoes biotransformation in liver and and to avoid first pass effect, it’s a new approach of delivery and offers a fast relieve from prostatic pain and infection and also restrict urinary outflow (relaxation of smooth muscle in the prostate and bladder neck). An attempt has been made to prepare fast dissolving tablets of tamsulosin hydrochloride using ethylcellulose,pectin,β cyclodextrin, mannitol, hydroxyl propyl methyl cellulose. Four different groups of formulations (A, N, S and B) with variation in tablet excipients were prepared by direct compression method. Tablet weight variation, hardness,friability, drug content, disintegration time and invitro dissolution were evaluated for each formulation and found satisfactory.

Keywords: Sublingual tablets, Tamsulosin hydrochloride, benign prostatic hyperplasia, urinary tract infection, fast relieve.

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